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 Table of Contents  
CASE REPORT
Year : 2015  |  Volume : 3  |  Issue : 1  |  Page : 94-96

Malignant proliferating trichilemmal tumor of the scalp with secondary infection in an elderly man


Department of General Surgery, Yenepoya Medical College, Mangalore, Karnataka, India

Date of Web Publication13-Apr-2015

Correspondence Address:
Dr. Saptarshi Paul
Department of General Surgery, Yenepoya Medical College, Mangalore - 575 018, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2321-4848.154954

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  Abstract 

A 65-year-old man presented with the complaints of a growth on the scalp, which ruptured spontaneously leading to bleeding and foul smelling discharge associated with severe pain. Examination revealed ulceroproliferative growth with slough and surrounding induration, infested with maggots. Histopathological examination revealed proliferating trichilemmal tumor (PTT) with secondary infection. Wide excision of the tumor was done with 1 cm margin all around it. PTT is a benign neoplasm that can rarely undergo malignant transformation thought to originate from trichilemmal cyst. Malignant PTT (MPTT) predominantly affects the scalp, eyelids, neck, and face and the treatment recommended being a wide local excision.

Keywords: Cyst, malignant, proliferating, trichilemmal, tumor


How to cite this article:
Paul S, Badekila H, Kumble AP. Malignant proliferating trichilemmal tumor of the scalp with secondary infection in an elderly man. Arch Med Health Sci 2015;3:94-6

How to cite this URL:
Paul S, Badekila H, Kumble AP. Malignant proliferating trichilemmal tumor of the scalp with secondary infection in an elderly man. Arch Med Health Sci [serial online] 2015 [cited 2019 Dec 7];3:94-6. Available from: http://www.amhsjournal.org/text.asp?2015/3/1/94/154954


  Introduction Top


Proliferating trichilemmal tumor (PTT) is a rare benign adnexal tumor of the skin with a female predilection and most commonly arises as a solitary mass on the scalp during the fourth to eighth decade of life; although other sites such as the upper extremities, back, gluteal region and vulva have been reported. Typical history is of a longstanding cystic lesion showing progressive growth over several months to years at the same site before rapid enlargement occurs. [1] Trauma and inflammation may induce a trichilemmal cyst to proliferate. [2],[5] Here we report a case of a malignant PTT (MPTT) in a 65-year-old male, which is quite rare (thorough literature search revealed only a handful of cases in males above 50 years).


  Case Report Top


A 65-year-old man came with the complaints of painful growth on the scalp for 4 years which burst spontaneously leading to ulceration, bleeding and foul smelling discharge. The clinical examination revealed an ulceroproliferative growth with slough and surrounding induration, infested with maggots. Maggots were removed, and an edge biopsy was done [Figure 1].
Figure 1: Photograph of the tumor postbiopsy, prior to wide excision

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Microscopically, the tumor showed stratified squamous epithelium arranged in a lobular pattern in the dermis, extending from the epidermis [Figure 2]. Abrupt keratinization was present in the center of the cell masses with palisading in the periphery [Figure 3] and [Figure 4]. Impression was PTT with secondary infection. Initially was treated with broad spectrum antibiotics and regular dressings, followed by wide excision of the tumor done with a 1 cm margin all around it.
Figure 2: Keratin pearls with squamous epithelium (H and E, ×200)

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Figure 3: Keratin pearl with palisading (H and E, ×200)

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Figure 4: Squamous cells in high resolution (H and E, ×400)

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  Discussion Top


Cutaneous tumors derived from the isthmus region of outer root sheath of hair follicles, which show trichilemmal keratinization, are trichilemmal cysts, proliferating trichilemmal cysts and malignant proliferating trichilemmal cysts. [9] In the recent years, there has been a steady rise in the number of skin biopsy specimens submitted for histopathological examination. Ordinary benign cutaneous cysts are very common in daily practice and may comprise a wide spectrum of entities, the benign end being represented by the trichilemmal cyst. Pathological examination of trichilemmal cysts remains the gold standard for detection of cytological and architectural atypia, and should be routinely performed even when there is no suspicion of a malignant process. A possibility of inheritance of pilar cysts in an autosomal-dominant mode, linked to chromosome 3, has been reported. Clinically, these may be mistaken for squamous cell carcinoma, basal cell carcinoma, nodular melanoma or keratoacanthoma. [1],[7] Most lesions measure several centimeters in diameter, but giant tumors of up to 25 cm have been described and are characterized by trichilemmal keratinization. Wilson - Jones first described PTT in 1966 as an entity that can clinically and histologically simulate squamous cell carcinoma. Initially classified as a pseudoepitheliomatous hyperplasia, a number of other terms like proliferating epidermoid cyst, pilar tumor of the scalp, proliferating trichilemmal cyst, proliferating epidermoid cyst, giant hair matrix tumor, hydatidiform keratinous cyst, trichochlamydocarcinoma and invasive hair matrix tumor have been used. [1] Metastasis from PTTs is rare. However, a sporadic malignant variant showing an aggressive clinical course and a tendency for lymph node and distal metastasis after treatment of the primary, or during initial presentation, has been reported. [1] It has been suggested that even conventional PTT, without atypical features, is a form of squamous cell carcinoma ab initio, described by the term proliferating tricholemmal cystic squamous carcinoma. Lesions showing a rounder, less complex border and an absence of nuclear crowding with increased mitoses should be termed proliferating tricholemmal cystic acanthoma accordingly. However, this view is not shared by all authors and the criteria for malignancy are not settled. Recently, a proposal for the definition of benign and malignant variants has been made with an attempt to classify the PTT into three morphological groups according to their histological appearances. These comprise:

  1. A benign PTT behaving in a benign manner,
  2. Low-grade MPPT is having potential for locally aggressive growth and,
  3. High-grade MPTT having metastastatic potential. [1],[9]


Features favoring benign behavior includes sharp circumscription, trichilemmal keratinization, lack of epidermal connection and low mitotic activity. Low-grade MPTT is distinguished from benign PTT by stromal invasion of the dermis and mild cytological abnormalities, whereas high-grade MPTT shows additional marked nuclear anaplasia [Figure 5]. [1],[3]
Figure 5: Classification of cystic lesions with trichilemmal keratinization

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Differential diagnoses include benign trichilemmal cyst, florid early phase pilomatrixoma, keratoacanthoma, and primary or metastatic squamous cell carcinoma, including cystic, verrucous, trichilemmal and spindle cell (sarcomatoid) variants. [1] Immunohistochemical demonstration of trichilemmal keratinization and reactivity with AE13, AE14 and cytokeratin 15 may help to distinguish high-grade MPTT from squamous cell carcinoma. [6] Loss of CD34 immunoreactivity also has been reported in MPTT. [1]

Simple excision is curative for benign PTT with an excellent prognosis. Local excision with a margin of normal tissue around has often been the standard treatment with no established role of additional therapeutic interventions such as radiation therapy and chemotherapy. Neo-adjuvant radiotherapy with radical surgery might be indicated for cases presenting with metastatic disease, although further study of similar aggressive tumors is necessary to establish the role of adjuvant therapy. [4] Intratumoral ethanol injection to reduce tumor mass and achieve hemostasis has been successfully tried by some authors for recurrent MPTT. [8] Bajoghli et al. [10] have tried a dual approach: Mohs micrographic surgery is utilized for a more discrete removal of malignant tissue, then DermaClose ® RC is used for wound revision, providing more effective wound closure than traditional suturing.

Malignant proliferating trichilemmal tumor has been reported in two patients with keratitis-ichthyosis-deafness syndrome and this group might warrant screening for PPT. [1]

 
  References Top

1.
Bury Y, Bloxham C. Profilerating trichilemmal tumour. Diagn Histopathol 2009;15:273-78.  Back to cited text no. 1
    
2.
Brownstein M, Arluk D. Proliferating trichilemmal cyst: A stimulant of squamous cell carcinoma. Cancer 1981;48:1207-14.  Back to cited text no. 2
    
3.
Folpe AL, Reisenauer AK, Mentzel T, Rütten A, Solomon AR. Proliferating trichilemmal tumors: Clinicopathologic evaluation is a guide to biologic behavior. J Cutan Pathol 2003;30:492-8.  Back to cited text no. 3
    
4.
Sau P, Graham JH, Helwig EB. Proliferating epithelial cysts. Clinicopathological analysis of 96 cases. J Cutan Pathol 1995;22:394-406.  Back to cited text no. 4
    
5.
Sethi S, Singh UR. Proliferating trichilemmal cyst: Report of two cases, one benign and the other malignant. J Dermatol 2002;29:214-20.  Back to cited text no. 5
    
6.
Mori O, Hachisuka H, Sasai Y. Proliferating trichilemmal cyst with spindle cell carcinoma. Am J Dermatopathol 1990;12:479-84.  Back to cited text no. 6
    
7.
Ye J, Nappi O, Swanson PE, Patterson JW, Wick MR. Proliferating pilar tumors: A clinicopathologic study of 76 cases with a proposal for definition of benign and malignant variants. Am J Clin Pathol 2004;122:566-74.  Back to cited text no. 7
    
8.
Takenaka H, Kishimoto S, Shibagaki R, Nagata M, Noda Y, Yasuno H. Recurrent malignant proliferating trichilemmal tumour: Local management with ethanol injection. Br J Dermatol 1998;139:726-9.  Back to cited text no. 8
    
9.
Garg PK, Dangi A, Khurana N, Hadke NS. Malignant proliferating trichilemmal cyst: A case report with review of literature. Malays J Pathol 2009;31:71-6.  Back to cited text no. 9
    
10.
Bajoghli AA, Yoo JY, Faria DT. Utilization of a new tissue expander in the closure of a large Mohs surgical defect. J Drugs Dermatol 2010;9:149-51.  Back to cited text no. 10
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]



 

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