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 Table of Contents  
MEDICAL HISTORY
Year : 2019  |  Volume : 7  |  Issue : 2  |  Page : 293-297

History of acne vulgaris and topical drugs in Unani medicine


Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, India

Date of Submission09-Sep-2019
Date of Decision20-Oct-2019
Date of Acceptance14-Nov-2019
Date of Web Publication16-Dec-2019

Correspondence Address:
Dr. Shabnam Ansari
Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/amhs.amhs_128_19

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  Abstract 


Acne is a common skin disorder that affects both adolescents and adults. Acne vulgaris affects about 85% of teenagers and may continue to adulthood. There are about two million visits to physicians per year for teenagers and the direct cost of acne treatment in the US exceeds $1 billion per year. Psychological, social, and emotional impairments that result from acne have been estimated to be equal and in some instances higher than that of diabetes, arthritis, epilepsy, and asthma. There is no ideal treatment for acne until now. Conventional drugs are associated with recurrence of acne and disastrous side effects on long-term usage. Unani medicines are gaining increased popularity due to their advantages, such as better patient tolerance, long history of use, fewer side effects, and relatively less expensive. Furthermore, they have provided good evidence for the treatment of a wide variety of difficult-to-cure diseases. More importantly, other than consumption as preventive or treatment remedy, they might be accompanied by synthetic drugs to reduce their side effects. Topical Unani drugs are an important part of the treatment strategy in dealing with acne. Many Unani topical drugs with anti-inflammation, wound healing, and antibacterial activities are used in different ways in the treatment of acne and other infective diseases. The present paper presents a list of topical Unani drugs used in the prevention and treatment of acne vulgaris for centuries.

Keywords: Acne vulgaris, herbal medicine, muhasa, Unani medicine, Unani topical drugs


How to cite this article:
Ansari S. History of acne vulgaris and topical drugs in Unani medicine. Arch Med Health Sci 2019;7:293-7

How to cite this URL:
Ansari S. History of acne vulgaris and topical drugs in Unani medicine. Arch Med Health Sci [serial online] 2019 [cited 2020 Apr 2];7:293-7. Available from: http://www.amhsjournal.org/text.asp?2019/7/2/293/273057




  Introduction Top


Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production, altered keratinization, inflammation, and bacterial colonization of hair follicles on the face, neck, chest, and back by Propionibacterium acnes.[1] Although early colonization with P. acnes and family history might have important roles in the disease, exactly what triggers acne and how treatment affects the course of the disease remain unclear.[2],[3] Other factors such as diet have been implicated, but not proven. Facial scarring due to acne affects up to 20% of teenagers. Acne can persist into adulthood, with detrimental effects on self-esteem.[1],[3] Acne lesions often leave lifelong scars and hyperpigmentation. Both scarring and hyperpigmentation may result in substantial disfigurement that can affect the patients' self-image, impacting considerably on their emotional health and quality of life.[2] Comparisons with other chronic illnesses have shown that acne patients have levels of social, psychological, and emotional impairments that are similar to those reported by patients with more serious diseases such as asthma, epilepsy, diabetes, back pain, or arthritis.[3] It is necessary to find an effective treatment to reverse this social and psychological disability.


  Background Top


According to epidemiological studies, acne is a common condition affecting 80% of young people between 12 and 18 years of age as well as 5% of females and 1% of males in adulthood. It is also the most common reason for consultation in private dermatology practices.[1] The average age of onset of acne is 11 years in girls and 12 years in boys.[4],[5] Acne is increasing in children of younger ages, with the appearance of acne in patients as young as 8 or 9 years of age. This trend toward earlier development of acne is thought to be related to the decreasing age of onset of puberty that has been observed in the United States.[6] Acne is more common in males in adolescence and early adulthood, which is a trend that reverses with increasing age.[7],[8] It is well known that adult acne is more common in women. Adult acne typically represents chronic acne persisting from adolescence, not new-onset disease. Acne ranks second only to skin ulcers and wounds in annual cost burden for dermatologic illness. A typical aspect of acne is the lesional pleomorphism with different lesions simultaneously present in the same patient.[4],[7],[8]

There is no ideal treatment for acne, although a suitable regimen for reducing lesions can be found for most patients. Good-quality evidence on the comparative effectiveness of common topical and systemic acne therapies is scarce. Topical therapies including benzoyl peroxide, retinoids, and antibiotics when used in combination usually improve control of mild-to-moderate acne.[1],[2] Treatment with combined oral contraceptives can help women with acne. Patients with more severe inflammatory acne usually need oral antibiotics combined with topical benzoyl peroxide to decrease antibiotic-resistant organisms. Oral isotretinoin is the most effective therapy and is used early in severe disease, although its use is limited by teratogenicity and other side effects. Availability, adverse effects, and cost limit the use of photodynamic therapy. New research is needed into the therapeutic comparative effectiveness and safety of the many products available and to better understand the natural history, subtypes, and triggers of acne.[1],[2],[7],[8]


  Acne Vulgaris in Unani Medicine Top


In Unani literature, the description, pathology, and treatment of acne vulgaris are present under the title of disease entity “basoore labaniya.” The meaning of “Basoor” in Arabic is “boil” and the meaning of “labaan” is “milk.” Due to the resemblance of the lesion (boils) to a point of milk, it is called “basoore labaniya.”[9] In acne vulgaris, the word “acne” probably came from the Greek for a “point” and “vulgaris” in Latin word meaning “common” because a person is more likely to develop acne than any other disease and the resemblance of acne lesion to a point is also called “acne vulgaris.”[10] According to classical Unani literature, Basoor (acne) is a type of warm (inflammation) which differs only in size. Acne is a small type of a warm. Ibn Sina (AD 980–1037) in his famous encyclopedia “Al Qanoon Fit-tibb” described the disease as sometime whitish boils appear at the nose and cheeks, resembling “nuqtae-labaan” (milk drop/point).[10] Other Unani physicians such as Tabri (AD 985) and Azam Khan (AD 1917) have defined the disease that mostly occurs at puberty, on the face and cheeks as whitish basoor (boil) appear like a “nuqtae sheer” (point or drop of milk) and upon squeezing, an oily secretion comes out like roghan-e-zard (ghee). In the classical Unani text “Kitab al-Hawi” by Zakariya Razi, it is mentioned as Atiasoos – “small and dry basoor of face”. It is hard and chronic in natural course.[10],[11],[12] According to Qarshi, it is a muttaaddi (infectious) disease in which small white eruptions appear on the face, nose, and cheeks and on pressing a cheesy material expressed out from it.[11]

The etiology is considered to be madda-e-sadeediyah (suppurative material), which comes toward the skin surface due to bukharat (vapors) of the body and is not resolved in the skin due to its viscosity. In other words, the yellow pus (madda-e-sadeediyah) originates due to the bukharat-e-badan (vapors) and later gets shifted toward skin and clog the pores.[10],[11],[12] The Unani scholars have pointed multifactorial etiology for the development of acne. Impurity in blood, hot and spicy food, indigestion, pregnancy, and menstruation are some of the causes. According to Hippocrates, variation in heat and moisture and climatic changes cause the imbalance of humors. Balance is restored using opposite treatment of heat and moisture in the diet and in hygiene.[13] The nature of eruption depends on the type of humor involved. When the eruption is limited to face and around the nose, white colored and without itching is called as basoore labaniya. The humor involved is balgham (phlegm). When the phlegm is viscid and thick, pus is formed.[11],[13] According to Tabri (AD 985), in his book of 10th cent AD “Firdausul Hikmat,” the lesion kooks red and swollen after it get ripped, “sadeed” (pus) and “keel” come out.[12] As per Azam Khan and Ibne Sina, on squeezing these lesion, a cheesy material like “Ghee” comes out from it.[9],[11] According to Kabeerudin, if pustules does not stop recurring or if the quantity of the “sadeed” (pus) is high, then after healing, they leave permanent scar. If “ghudade duhaniya” gets destroyed, hair does not grow there again.[11]

Similarly, a severe variety of acnes are also mentioned in Unani literature followed by therapies for prevention and treatment. The line of treatment of acne is based upon the root cause of the disease as per the dominated humors. “Istafragh” (Evacuation) and “Tanqiyah-e-badan” (detoxification) by systemic drugs such as joshanda aftimoon or habbe ayarijMusaffiyate khoon” (blood purifiers) are also advised. Indigestion, constipation, and menstrual irregularity are treated. Topical formulation to prevent excessive oiliness and to provide cleansing, soothing, alleviating inflammation and swelling, healing pustules and wounds, and lightening scars have been mentioned.[9],[11],[12] Hence, traditional drugs from AYUSH side can be utilized in place of allopathic drugs to prevent and control acne reoccurrence.


  Topical Unani Drugs Top


Unani physicians have been treating acne vulgaris for centuries. Unani system of medicine provides a treatment approach based on the use of oral blood purifiers and alteration of abnormality of a specific humor along with usage of topical Unani drugs which are anti-inflammatory, analgesics, wound healer and with detergent property altogether best tolerated by adolescents and adults. Several topical drugs are mentioned in the treatment of acne in Unani classical text. Some of which are mentioned in [Table 1].
Table 1: Topical single drugs for acne in Unani medicine

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Compound topical formulations for acne in Unani medicine:

  1. Tiryaq muhasa[42]
  2. Dawae bassor labani[17]
  3. Tilae akbar[29]
  4. Zimad muhasa[22]
  5. Tilae muhasa[53]
  6. Habbe kalaf[13]
  7. Zimad majali[13]
  8. Dawae muhasa[13]
  9. Dawae chuhara[13]
  10. Ubtan ajeeb.[13]



  Conclusion Top


Acne vulgaris is a very common skin disorder which can present with inflammatory and noninflammatory lesions chiefly on the face but can also occur on the upper arms, trunk, and back. Acne vulgaris is an inflammatory disorder of the pilosebaceous unit, which runs a chronic course and it is self-limiting. Acne vulgaris is triggered by P. acnes in adolescence, under the influence of normal circulating dehydroepiandrosterone. Acne vulgaris is a chronic condition affecting more than 85% of adolescents and two-third of adults aged 18 years and older. Patients experience psychological burdens such as depression, anxiety, and low self-esteem because of acne. A wide variety of treatment regimens exist for acne vulgaris including benzoil peroxide, retinoids, isotretinoids, keratolytic soaps, alpha hydroxy acids, azelaic acid, salicylic acid as well as hormonal, anti-androgen or anti-seborrheic treatments. The direct injection of steroids into inflamed cysts, microdermabrasion, chemical peels, radiofrequencies, light, or lasers have been shown to result in the relief of acne; however, none of these regimens are free of side effects. Furthermore, more investigations are needed to clarify the exact role of these methods in therapy. Long usage of antibiotics causes antibiotic resistance and gastrointestinal and kidney disorders. Other the other hand, Unani medicine provides a cost-effective traditional prevention and treatment approach with negligible side effects upon long-term usage. Oral usage of blood purifying plants is indeed a common strategy in combating the disease. Topical Unani drugs are also extensively used in the treatment of different varieties of acne including the scars. Some of the Unani drugs are used singly or used in combination with other drugs (compound) in paste, ointment, oil, or liquid form. Sometimes, these drugs are used alone or in combination with allopathic drugs to treat diseases. The single Unani drugs such as dill, European birthwort, milkvetch, margosa tree, lemon, coriander, mango ginger, fig, fumitory, black hellebore, iris, henna, Indian kamala, minimum/vermilion, black cumin, olive, screw pine, bitter almond, pomegranate flowers, radish, and rose water and compound topical preparation such as tiryaq muhasa, dawae bassor labani, tilae akbar, zimad muhasa, tilae muhasa, habbe kalaf, zimad majali, dawae muhasa, dawae chuhara, and ubtan ajeeb have been used by Unani physicians for local application on acne lesion since centuries with beneficial outcomes. Hence, clinical studies should be conducted on the line of mentioned Unani treatment to substantiate their efficacy in prevention and control of acne vulgaris.

Acknowledgments

The author is thankful to the librarian and library assistant of the department of moalajat and school of Unani medicine, Jamia Hamdard, New Delhi.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Dreno B, Daniel F, Allaert FA, Aube I. Acne: Evolution of the clinical practice and therapeutic management of acne between 1996 and 2000. Eur J Dermatol 2003;13:166-70.  Back to cited text no. 1
    
2.
Aktan S, Ozmen E, Sanli B. Anxiety, depression, and nature of acne vulgaris in adolescents. Int J Dermatol 2000;39:354-7.  Back to cited text no. 2
    
3.
Mallon E, Newton JN, Klassen A, Stewart-Brown SL, Ryan TJ, Finlay AY. The quality of life in acne: A comparison with general medical conditions using generic questionnaires. Br J Dermatol 1999;140:672-6.  Back to cited text no. 3
    
4.
Dreno B, Poli F. Epidemiology of acne. Dermatology 2003;206:7-10.  Back to cited text no. 4
    
5.
Schäfer T, Nienhaus A, Vieluf D, Berger J, Ring J. Epidemiology of acne in the general population: The risk of smoking. Br J Dermatol 2001;145:100-4.  Back to cited text no. 5
    
6.
Friedlander SF, Eichenfield LF, Fowler JF Jr., Fried RG, Levy ML, Webster GF, et al. Acne epidemiology and pathophysiology. Semin Cutan Med Surg 2010;29:2-4.  Back to cited text no. 6
    
7.
Goulden V, Clark SM, Cunliffe WJ. Post-adolescent acne: A review of clinical features. Br J Dermatol 1997;136:66-70.  Back to cited text no. 7
    
8.
Goulden V, Stables GI, Cunliffe WJ. Prevalence of facial acne in adults. J Am Acad Dermatol 1999;41:577-80.  Back to cited text no. 8
    
9.
Sina I. In: Al-Qanoon. Hkm Ghulam Hussain Kantoori. Vol. 3. Lahore: Bashir and Sons; 1984. p. 161-3.  Back to cited text no. 9
    
10.
Zouboulis CC, Katsambas AD, Kligman AM. Pathogenesis and Treatment of Acne and Rosaceae. US: Springer; 2014. p. 5-9.  Back to cited text no. 10
    
11.
Khan A. Ikseer Azam. Lucknow: Munshi Nawal Kishore Press; 1917. p. 450.  Back to cited text no. 11
    
12.
Tabri M. Moalijaat Buqratiyah. New Delhi: CCRUM; 1995. p. 252.  Back to cited text no. 12
    
13.
Khan GJ. Makhzanul Ilaj. Vol 2. Lahore: Shaikh Muhammad Basheer and Sons; 1978. p. 1144-5.  Back to cited text no. 13
    
14.
Chauhan NM. Sadri Mujarrabat. Lahore: Idara Takmeelu Tibb; 199. p. 23.  Back to cited text no. 14
    
15.
Fernando R, Rahde AF. Abrus precatorius L. Available from: ://www.inchem.org/documents/pims/plant/abruspre.htmhttp. [Last accessed on 2019 Sep 12].  Back to cited text no. 15
    
16.
Tabasum H, Ahmad T, Anjum F, Rehman H. The effect of Unani antiacne formulation (Zimade Muhasa) on acne vulgaris: A single blind, randomized, controlled clinical trial. J Pak Assoc Dermatol 2014;24:319-26.   Back to cited text no. 16
    
17.
Khan A. Muheete Azam. Vol. 4. Lucknow: Munshi nawal Kishore Press; 1920 p. 138.  Back to cited text no. 17
    
18.
Vora J, Srivastava A, Modi H. Antibacterial and antioxidant strategies for acne treatment through plant extracts. Inform Med Unlocked 2018;13:128-32.  Back to cited text no. 18
    
19.
Nipanikar S, Chitlange S, Nagore D. Evaluation of anti-inflammatory and antimicrobial activity of AHPL/AYCAP/0413 capsule. Pharmacognosy Res 2017;9:273-6.  Back to cited text no. 19
    
20.
Gloor M, Schorch B, Hoeffler U. The feasibility of replacing antibiotics by quaternary ammonium compounds in topical antimicrobial acne therapy. Arch Dermatol Res 1979;265:207-12.  Back to cited text no. 20
    
21.
Aggarwal BB, Prasad S, Reuter S, Kannappan R, Yadev VR, Park B, et al. Identification of novel anti-inflammatory agents from ayurvedic medicine for prevention of chronic diseases: “reverse pharmacology” and “bedside to bench” approach. Curr Drug Targets 2011;12:1595-653.  Back to cited text no. 21
    
22.
All India Unani Tibbi Conference. Qarabadeen Majeedi. New Delhi: All India Unani Tibbi Conference; 1986. p. 155-94.  Back to cited text no. 22
    
23.
Fred-Jaiyesimi A, Ajibesin KK, Tolulope O, Gbemisola O. Ethnobotanical studies of folklore phytocosmetics of South West Nigeria. Pharm Biol 2015;53:313-8.  Back to cited text no. 23
    
24.
Krasteva I, Platikanov S, Nikolov S, Kaloga M. Flavonoids from Astragalus hamosus. Nat Prod Res 2007;21:392-5.  Back to cited text no. 24
    
25.
Kapoor S, Saraf S. Topical herbal therapies an alternative and complementary choice to combat acne. Res J Med Plants 2011;5:650-69.  Back to cited text no. 25
    
26.
Zilurrehman H. Bayaze Wahidi. Aligarh: Shifa-ul Malik Memorial Committee; 1974. p. 221.  Back to cited text no. 26
    
27.
Shinkafi SA, Anusa H. Antibacterial activity of citrus Limon on acne vulgaris (pimples). IJSIT 2013;2:397-409.  Back to cited text no. 27
    
28.
Khan MH. Datoorul Ilaj. Lucknow: Munshi Nawal Kishore Publishing House; 1984. P. 294  Back to cited text no. 28
    
29.
Geelani G. Makhzane Hikmat. Vol. 2. Lahore: Basheer and Sons; 1996. p. 689-91.  Back to cited text no. 29
    
30.
Sathishkumar P, Preethi J, Vijayan R, Mohd Yusoff AR, Ameen F, Suresh S, et al. Anti-acne, anti-dandruff and anti-breast cancer efficacy of green synthesised silver nanoparticles using Coriandrum sativum leaf extract. J Photochem Photobiol B 2016;163:69-76.  Back to cited text no. 30
    
31.
Pandey C, Karadi RV, Bhardwaj KL, Sahu KA. Screening of selected herbal plants for anti acne properties. Int J Drug Dev Res 2012;4:216-22.  Back to cited text no. 31
    
32.
Sina I. Al Qanoon Fit Tibb. Vol. 4. Lucknow: Munshi Nawal Kishore Publishing House; 1030. p. 381.  Back to cited text no. 32
    
33.
Vaghasiya CM, Bhatt PV, Pandya D. Evaluation of anti-acne activity of Ficus carica as an evidence of current usage in herbal formulations. Int J Pharm Tech Res 2015;8:356-9.  Back to cited text no. 33
    
34.
Jowkar F, Jamshidzadeh A, Mirzadeh Yazdi A, Pasalar M. The effects of fumaria parviflora L extract on chronic hand eczema: A randomized double-blind placebo controlled clinical trial. Iran Red Crescent Med J 2011;13:824-8.  Back to cited text no. 34
    
35.
Nagel K, Schneemann I, Kajahn I, Labes A, Wiese J, Imhoff J. Beneficial effects of 2,4-diacetylphloroglucinolproducing Pseudomonads on the marine alga Saccharina latissimi. Aquat Microb Ecol 2012;67:239-49.  Back to cited text no. 35
    
36.
Laminaria saccharina Extract. Available from: https://incidecoder.com/ingredients/laminaria-saccharina-extract. [Last accessed on 2019 Sep 22].  Back to cited text no. 36
    
37.
Gupta A, Bonde SR, Gaikwad S, Ingle A, Gade AK, Rai M. Lawsonia inermis-mediated synthesis of silver nanoparticles: Activity against human pathogenic fungi and bacteria with special reference to formulation of an antimicrobial nanogel. IET Nanobiotechnol 2014;8:172-8.  Back to cited text no. 37
    
38.
Hyndiuk RA, Burd EM, Hartz A. Efficacy and safety of mercuric oxide in the treatment of bacterial blepharitis. Antimicrob Agents Chemother 1990;34:610-3.  Back to cited text no. 38
    
39.
Qidwai A, Pandey M, Kumar R, Dikshit A. Comprehensive evaluation of pharmacological properties of Olea europaea L. for Cosmeceuticals prospects. Clin Phytosci 2017;3:12.  Back to cited text no. 39
    
40.
Londonkar R, Kamble A, Reddy VC. Anti-inflammatory activity of Pandanus odoratissimus extract. Int J Pharmacol 2010;6:311-4.  Back to cited text no. 40
    
41.
Londonkar R, Kamble A. Hepatotoxic and in vivo antioxidant potential of Pandanus odoratissimus against carbon tetrachloride induced liver injury in rats. Orient Pharm Exp Med 2011;11:229-34.  Back to cited text no. 41
    
42.
Hajazi MR. Bayaze Hajazi. Lahore: Bashir and Sons; 1967. p. 56.  Back to cited text no. 42
    
43.
Isfahlan AJ, Mahmoodzadeh A, Hassanzadch A, Heidari R, Jamai R. Anti-oxidant and anti radical activities of the phenolic extracts of the hulls and shells of the Iranian almond (Prunus Amygdalus). Turk J Biol 2010;34:165-73.  Back to cited text no. 43
    
44.
Lee CJ, Chen LG, Liang WL, Wang CC. Multiple activities of Punica granatum linne against acne vulgaris. Int J Mol Sci 2017;18. pii: E141.  Back to cited text no. 44
    
45.
Chaturvedi P. Inhibitory response of Raphanus sativus on lipid peroxidation in albino rats. Evid Based Complement Alternat Med 2008;5:55-9.  Back to cited text no. 45
    
46.
Sinha P, Srivastava S, Mishra N, Yadav NP. New perspectives on antiacne plant drugs: Contribution to modern therapeutics. Biomed Res Int 2014;2014:301304.  Back to cited text no. 46
    
47.
Chughtayee GM, Fasihuddin H. Bayaze Firozi. Vol. 3. Lahore: Basheer and Sons; 1995. p. 728.  Back to cited text no. 47
    
48.
Elmore AR, Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite. Int J Toxicol 2003;22 Suppl 1:37-102.  Back to cited text no. 48
    
49.
Vohora SB, Naqvi SA, Kumar I. Antipyretic, analgesic and antimicrobial studies on sisymbrium irio. Planta Med 1980;38:255-9.  Back to cited text no. 49
    
50.
Sandeep Varma R, Shamsia S, Thiyagarajan OS, Vidyashankar S, Patki PS. Yashada bhasma (Zinc calx) and tankana (Borax) inhibit propionibacterium acne and suppresses acne induced inflammation in vitro. Int J Cosmet Sci 2014;36:361-8.  Back to cited text no. 50
    
51.
Campisano A, Ometto L, Compant S, Pancher M, Antonielli L, Yousaf S, et al. Interkingdom transfer of the acne-causing agent, propionibacterium acnes, from human to grapevine. Mol Biol Evol 2014;31:1059-65.  Back to cited text no. 51
    
52.
Pinheiro CD, Pontes GS, Pinheiro CC. Antimicrobial Activity of Essential oil from Zingiber zerumbet (l.) Smith against Propionibacterium Acnes. Availablew from: https://www.sbmicrobiologia.org.br/29cbm-anais/resumos/15/R1046-1.PDF. [Last accessed on 2019 Sep 20].  Back to cited text no. 52
    
53.
Lubhaya R. Delhi ke Muntakhib Murakkabat. Delhi: Goswami Kutub Khana; 1994. p. 204.  Back to cited text no. 53
    



 
 
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Abstract
Introduction
Background
Acne Vulgaris in...
Topical Unani Drugs
Conclusion
References
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