Archives of Medicine and Health Sciences

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 7  |  Issue : 2  |  Page : 191--194

Peripheral blood level of natural killer cells in pregnant women with recurrent spontaneous abortion during the 6–12 weeks gestation


Sung-Guk Kim, Mi-Yong Paek, Il Gyong Ko 
 Department of Obstetrics and Gynecology, Pyongyang Medical College, Kim Il Sung University, Pyongyang, Democratic People's Republic of Korea

Correspondence Address:
Dr. Sung-Guk Kim
Department of Obstetrics and Gynecology, Pyongyang Medical College, Kim Il Sung University, Pyongyang
Democratic People's Republic of Korea

Background and Aim: The study was performed to confirm the clinical characteristics and peripheral blood level of natural killer (NK) cells as a diagnostic index in women with recurrent spontaneous abortion (RSA) comparing with normal pregnant women. Materials and Methods: Consultation with all patients was conducted to obtain the number and timing of previous miscarriages and signs and symptoms of abortion progress. Assessment of peripheral blood NK cell level was performed by flowcytometric analyses. Results: Women with RSA have brown-colored vaginal bleeding and history of more than three consecutive miscarriage, while the percentage of peripheral blood NK cell within blood lymphocytes was more than 18.1%. Conclusion: In the current study, RSA patients (6–12 weeks') showed significantly higher level of peripheral blood NK cells (>18.1%) compared to that of normal gravidas. Further studies are required to clarify the precise mechanism how NK cells affect the progression of healthy pregnancy and investigate clinical evidence whether therapies to lower the level of NK cells can decrease the rate of RSA.


How to cite this article:
Kim SG, Paek MY, Ko IG. Peripheral blood level of natural killer cells in pregnant women with recurrent spontaneous abortion during the 6–12 weeks gestation.Arch Med Health Sci 2019;7:191-194


How to cite this URL:
Kim SG, Paek MY, Ko IG. Peripheral blood level of natural killer cells in pregnant women with recurrent spontaneous abortion during the 6–12 weeks gestation. Arch Med Health Sci [serial online] 2019 [cited 2020 Aug 14 ];7:191-194
Available from: http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2019;volume=7;issue=2;spage=191;epage=194;aulast=Kim;type=0