Archives of Medicine and Health Sciences

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 7  |  Issue : 2  |  Page : 206--211

Does Thyroid dysfunction correlates with iron overload in Eβ thalassemia patients? A study from a tertiary care thalassemia center in India


Shuvraneel Baul1, Tuphan Kanti Dolai1, Pranab Kumar Sahana2, Rajib De1, Prakas Kumar Mandal1, Prantar Chakrabarti1 
1 Department of Hematology, NRS Medical College, Kolkata, West Bengal, India
2 Department of Endocrinology, NRS Medical College, Kolkata, West Bengal, India

Correspondence Address:
Dr. Prakas Kumar Mandal
8C/1/N, Roy Para Road, Kolkata - 700 050, West Bengal
India

Background and Aim: Large number of Haemoglobin E-beta thalassaemia (Hb E/β-thalassaemia) patients show iron overloads and related end-organ damage irrespective of transfusion requirements. The prevalence of hypothyroidism in Indian population is approximately 11%. We studied the relationship between thyroid dysfunction and iron overload in Hb E/β-thalassaemia. Materials and Methods: The study included Eβ-thalassemia patients above the age of 10 years. Patient's serum ferritin level evaluated for the evaluation of iron status and thyroid-stimulating hormone, FT4, T3 for thyroid function status. Results: The study was conducted from January 2016 to December 2017. Of 50 Eβ-thalassemia patients, there were 22 females; the mean age was 19 years (range: 12–47 years). A total of 22 (44%) patients showed thyroid dysfunction; overt hypothyroidism seen in 6 (12%) patients with mean ferritin level of 1077 ng/ml and subclinical hypothyroidism seen in 16 (32%) patients with mean ferritin level of 1200 ng/ml. Normal thyroid function seen in 28 (56%) of patients with mean ferritin level of 1155 ng/ml. Conclusion: The prevalence of thyroid dysfunction was found to be higher in Hb E/β-thalassaemia patients, but a definite correlation with the serum ferritin level could not be established.


How to cite this article:
Baul S, Dolai TK, Sahana PK, De R, Mandal PK, Chakrabarti P. Does Thyroid dysfunction correlates with iron overload in Eβ thalassemia patients? A study from a tertiary care thalassemia center in India.Arch Med Health Sci 2019;7:206-211


How to cite this URL:
Baul S, Dolai TK, Sahana PK, De R, Mandal PK, Chakrabarti P. Does Thyroid dysfunction correlates with iron overload in Eβ thalassemia patients? A study from a tertiary care thalassemia center in India. Arch Med Health Sci [serial online] 2019 [cited 2020 Sep 28 ];7:206-211
Available from: http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2019;volume=7;issue=2;spage=206;epage=211;aulast=Baul;type=0