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  Indian J Med Microbiol
 

Figure 2: Overview of the angiotensin-converting enzyme 2 – angiotensin 1–7 pathway. Angiotensin-converting enzyme 2 and prolylcarboxypeptidase convert angiotensin II to angiotensin 1–7. Angiotensin-converting enzyme 2 can also convert angiotensin I to angiotensin 1–9, which is then cleaved by either neprilysin or angiotensin-converting enzyme to yield angiotensin 1–7. The membrane-bound angiotensin-converting enzyme 2 can be cleaved by the metalloproteinase ADAM 17, forming a soluble form of angiotensin-converting enzyme 2. The physiological relevance of soluble angiotensin-converting enzyme 2 is not fully understood

Figure 2: Overview of the angiotensin-converting enzyme 2 – angiotensin 1–7 pathway. Angiotensin-converting enzyme 2 and prolylcarboxypeptidase convert angiotensin II to angiotensin 1–7. Angiotensin-converting enzyme 2 can also convert angiotensin I to angiotensin 1–9, which is then cleaved by either neprilysin or angiotensin-converting enzyme to yield angiotensin 1–7. The membrane-bound angiotensin-converting enzyme 2 can be cleaved by the metalloproteinase ADAM 17, forming a soluble form of angiotensin-converting enzyme 2. The physiological relevance of soluble angiotensin-converting enzyme 2 is not fully understood