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  Indian J Med Microbiol
 

Figure 1: (a) Control liver showing normal hepatocytes. (b) Liver of rat treated with 150 mg/kg ifosfamide on the 7th day showing periportal and pericentral necroses of hepatocytes. (c-e) Liver of rats pretreated with 10, 20, and 40 mg/kg of lycopene daily for 7 days before treatment with ifosfamide on the 7th day showing normal hepatocytes in the pericentral zones (H and E, ×200)

Figure 1: (a) Control liver showing normal hepatocytes. (b) Liver of rat treated with 150 mg/kg ifosfamide on the 7<sup>th</sup> day showing periportal and pericentral necroses of hepatocytes. (c-e) Liver of rats pretreated with 10, 20, and 40 mg/kg of lycopene daily for 7 days before treatment with ifosfamide on the 7<sup>th</sup> day showing normal hepatocytes in the pericentral zones (H and E, ×200)