| ORIGINAL ARTICLE |
|
| Year : 2013 | Volume
: 1
| Issue : 1 | Page : 6-9 |
|
|
Anti-convulsant activity of ethanolic extract of Moringa concanensis leaves in Swiss albino mice
Anu Elizabeth Joy1, Shankar Bhat Kunhikatta1, Shyamjith Manikkoth2
1 Department of Physiology, Yenepoya Medical college, Mangalore, Karnataka, India
2 Department of Pharmacology, Yenepoya Medical college, Mangalore, Karnataka, India
Correspondence Address:
Shyamjith Manikkoth
Department of Pharmacology, Yenepoya Medical College, Mangalore - 575 018, Karnataka
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2321-4848.113548
|
|
|
Objectives : To investigate the anti-convulsant activity of ethanolic extract of Moringa concanensis leaves on maximal electroshock-induced seizures (MES) and pentylenetetrazole (PTZ)-induced seizures in Swiss albino mice. Materials and Methods : The ethanolic extract of Moringa concanensis leaves (200 mg/kg, i.p) was studied for its anti-convulsant effect on MES and PTZ-induced seizures in Swiss albino mice. In MES seizures, suppression of tonic hind limb extension was noted. In PTZ seizures, abolition of the convulsions was noted. Results : The ethanolic extract of the leaves of Moringa concanensis (200 mg/kg, i.p) significantly (P < 0.001) abolished the hind limb extension induced by MES. The same dose also significantly (P < 0.001) protected the animals from PTZ-induced tonic convulsions. Conclusion : The data suggests that the ethanolic extract of Moringa concanensis leaves may produce its anti-convulsant effects via multiple mechanisms since it abolished the hind limb extension induced by MES as well as abolished seizures produced by PTZ. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
