| REVIEW ARTICLE |
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| Year : 2013 | Volume
: 1
| Issue : 2 | Page : 136-139 |
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Field cancerization: A review
M Aparna, Prashanth Shenai, Laxmikanth Chatra, KM Veena, Prasanna Kumar Rao, Rachana V Prabhu, KA Shahin
Department of Oral Medicine and Radiology, Yenepoya Dental College, Yenepoya University, Deralakatte, Mangalore, Karnataka, India
Correspondence Address:
Laxmikanth Chatra
Department of Oral Medicine and Radiology, Yenepoya Dental College, Yenepoya University, Deralakatte, Mangalore - 575 018, Karnataka
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2321-4848.123026
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Concept of field cancerization was first introduced over six decades ago in the setting of oral cancer. Later, field cancerization involving histologic and molecular changes of neoplasms and adjacent tissue was explained. Field cancerization involves the lateral spread of pre-malignant or malignant disease and contributes to the recurrence of head and neck tumors. The overall hypothesis underlying this work is that endothelial cells actively participate in tumor cell invasion by secreting chemokines and creating a chemotactic gradient for tumor cells. The article tries to explain the conflicting aspects of field cancerization in the setting of oral cancer. |
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