Archives of Medicine and Health Sciences

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 1  |  Issue : 1  |  Page : 6--9

Anti-convulsant activity of ethanolic extract of Moringa concanensis leaves in Swiss albino mice


Anu Elizabeth Joy1, Shankar Bhat Kunhikatta1, Shyamjith Manikkoth2 
1 Department of Physiology, Yenepoya Medical college, Mangalore, Karnataka, India
2 Department of Pharmacology, Yenepoya Medical college, Mangalore, Karnataka, India

Correspondence Address:
Shyamjith Manikkoth
Department of Pharmacology, Yenepoya Medical College, Mangalore - 575 018, Karnataka
India

Objectives : To investigate the anti-convulsant activity of ethanolic extract of Moringa concanensis leaves on maximal electroshock-induced seizures (MES) and pentylenetetrazole (PTZ)-induced seizures in Swiss albino mice. Materials and Methods : The ethanolic extract of Moringa concanensis leaves (200 mg/kg, i.p) was studied for its anti-convulsant effect on MES and PTZ-induced seizures in Swiss albino mice. In MES seizures, suppression of tonic hind limb extension was noted. In PTZ seizures, abolition of the convulsions was noted. Results : The ethanolic extract of the leaves of Moringa concanensis (200 mg/kg, i.p) significantly (P < 0.001) abolished the hind limb extension induced by MES. The same dose also significantly (P < 0.001) protected the animals from PTZ-induced tonic convulsions. Conclusion : The data suggests that the ethanolic extract of Moringa concanensis leaves may produce its anti-convulsant effects via multiple mechanisms since it abolished the hind limb extension induced by MES as well as abolished seizures produced by PTZ.


How to cite this article:
Joy AE, Kunhikatta SB, Manikkoth S. Anti-convulsant activity of ethanolic extract of Moringa concanensis leaves in Swiss albino mice.Arch Med Health Sci 2013;1:6-9


How to cite this URL:
Joy AE, Kunhikatta SB, Manikkoth S. Anti-convulsant activity of ethanolic extract of Moringa concanensis leaves in Swiss albino mice. Arch Med Health Sci [serial online] 2013 [cited 2021 Apr 18 ];1:6-9
Available from: https://www.amhsjournal.org/article.asp?issn=2321-4848;year=2013;volume=1;issue=1;spage=6;epage=9;aulast=Joy;type=0