Archives of Medicine and Health Sciences

: 2015  |  Volume : 3  |  Issue : 2  |  Page : 282--284

A case report of white grain eumycetoma caused by Scedosporium apiospermum in a tertiary care hospital of the Eastern India

Kalidas Rit1, Rajdeep Saha2, Parthasarathi Chakrabarty3, Bipasa Chakraborty1,  
1 Department of Microbiology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India
2 Department of Microbiology, National Medical College, Kolkata, West Bengal, India
3 Department of Microbiology, Sagar Dutta Medical College, Kolkata, West Bengal, India

Correspondence Address:
Kalidas Rit
70B T. C. Mukherjee Street, Rishra Post, Hooghly - 712 248, West Bengal


Scedosporium apiospermum and its asexual state Pseudallecheria boydiiare increasingly recognized as an opportunistic pathogen. Here, we describe a white grain eumycetoma of left foot of a 48-year-old female caused by S. apiospermum. Treatment with oral voriconazole was successful.

How to cite this article:
Rit K, Saha R, Chakrabarty P, Chakraborty B. A case report of white grain eumycetoma caused by Scedosporium apiospermum in a tertiary care hospital of the Eastern India.Arch Med Health Sci 2015;3:282-284

How to cite this URL:
Rit K, Saha R, Chakrabarty P, Chakraborty B. A case report of white grain eumycetoma caused by Scedosporium apiospermum in a tertiary care hospital of the Eastern India. Arch Med Health Sci [serial online] 2015 [cited 2022 Dec 4 ];3:282-284
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The asexual state of the ascomycete Scedosporium apiospermum and its sexual state Pseudallescheria apiospermum (previously known as Pseudallescheria boydii) is frequently isolated from soil, manure, and decaying vegetation. [1] It commonly causes systemic disease in immunocompromised individuals and eumycetoma in immununocompetent patients. [2] Eumycetoma is a chronic granulomatous infection most commonly affecting muscles, bones, cartilage and joints of lower extremities particularly the foot. It has a classical triad of soft tissue swelling, draining sinus tracts, and expulsion of grains. [3] Here, we describe a white grain eumycetoma caused by S. apiospermum in an immunocompetent individual that was successfully cured with oral voriconazole therapy.

 Case Report

A 48-year-old woman from rural Bengal presented with a 1-year 8 months history of progressive pain and swelling of the left foot [Figure 1]. There was a history of injury left foot while doing agricultural work. Plain X-ray of affected foot showed widening of joint spaces with periosteal reaction, bone destruction, erosive changes, and demineralization [Figure 2]. The patient was non-diabetic and normotensive. Routine blood examination revealed no abnormality. Her blood sample was nonreactive to HIV1 and HIV2 antibodies. Expressed material from discharging sinus tract examined under a microscope after mixing with 10% potassium hydroxide revealed whitish grain containing broad septate hyphae. Hematoxilin and eosin stain demonstrated a granulomatous response on dermice and subcutaneous tissue containing localized abscesses with spherical white grain eumycetoma [Figure 3]. Culture of a sample of a biopsy on Sabouraud glucose agar revealed fungal growth identified as S. apiospermum. Lactophenol cotton blue preparation of fungal colony when examined under a microscope revealed branching septate hyphae having ovoid conidia with thick walls at the end of the conidiophores.{Figure 1}{Figure 2}{Figure 3}

The patient was initially treated with oral itraconazole therapy (200 mg/day) for 1½ years but there was no improvement of her disease condition. The patient was not willing to accept any surgical intervention. Therapy with oral voriconazole at a dose of 200 mg twice daily was started, and she showed clinical improvement. Therapy was continued for 1-year and 2 months. At follow-up, 3 years later, her clinical signs had been completely resolved [Figure 4].{Figure 4}


S. apiospermum causes infection in both immunocompetent and immunocompromised individuals. This fungus is commonly associated with eumycetoma but disseminated, and invasive infections with this fungus are seen primarily in immunocompromised hosts. Here, the patient was immunocompetent, and the diagnosis was confirmed by both microscopically and positive culture of causative pathogen. Scedosporiosis is reported infrequently. Eumycetoma due to S. apiospermum is more common in the USA and uncommon in the Indian subcontinent. There are very few reports of infections caused by this pathogen from India. [4] Mycetoma because of actinomycetes is common in Southern India, and mycetoma due to the fungal cause is more common in Northern India. There are only occasional reported cases of white grain eumycetoma around India. Singh and Venugopal reported cases of white grain eumycetoma around the Indian subcontinent. [5],[6] Maiti et al. reported few cases of eumycetoma due to S. apiospermum in this part of the country. [7],[8]

Before the advent of newer antifungal more effective against S. apiospermum, the most successful approach to control of eumycetoma was surgical, mostly amputation. However, the procedure of amputation is disfiguring and also traumatic to the patient and may compromise day to day activity. There are also chances of recurrence of mycetoma on the amputation stump. The correct diagnosis of white grain eumycetoma is important because S. apiospermum is resistant to a variety of commonly used antifungal agents. S. apiospermum is usually not amenable to ketoconazole therapy and frequently resistant to itraconazole in vitro. However newer azoles like voriconazole have shown some promise. [9] Voriconazole showed higher in vitro activity against S. apiospermum with lower minimum inhibitory concentration value in comparison to other available antifungal agents. [10] Voriconazole has been used in a few cases of white grain eumycetoma with success. [10],[11] Moreover, although expensive, it should be considered as a first line antifungal agent for the treatment of eumycetoma caused by S. apiospermum. [12],[13] The dose requirement and optimum duration of therapy should be individualized.


Dr. P. K. Maiti, MD, Prof. and Head Department of Microbiology, Institute of Post Graduate Medical Education and Research. 244 AJC Bose Road, Kolkata - 700 020.

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Conflicts of interest

There are no conflicts of interest.


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