Archives of Medicine and Health Sciences

SPECIAL ARTICLE
Year
: 2019  |  Volume : 7  |  Issue : 1  |  Page : 104--111

Epilepsy and depression: An update


Marco Mula 
 Atkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust, London, United Kingdom

Correspondence Address:
Dr. Marco Mula
Atkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust, Blackshaw Road, London SW17 0QT
United Kingdom

Depression is one of the most frequent comorbidities in patients with epilepsy affecting 1 in 4 patients, and this is due to psychological and neurobiological reasons. This is a narrative review of the epidemiological, neurobiological, and clinical aspects of depression in epilepsy. References have been identified through Medline/PubMed searches till February 2019 using the terms “epilepsy” AND “depression”. Additional articles were identified from the author's own files and from chosen bibliographies. Epilepsy and depression have a complex bidirectional relationship suggesting shared neurobiological mechanisms and the possibility that depression is a premorbid symptom of some epilepsy syndromes. The phenomenology of depression can be different from that seen outside epilepsy, but epilepsy-specific screening instruments, such as the Neurological Disorders Depression Inventory for Epilepsy, are now available to be used in routine clinical practice. Sertraline and citalopram can be considered first-line treatment in moderate to severe depression while psychological treatments should always be offered to mild to moderate cases.


How to cite this article:
Mula M. Epilepsy and depression: An update.Arch Med Health Sci 2019;7:104-111


How to cite this URL:
Mula M. Epilepsy and depression: An update. Arch Med Health Sci [serial online] 2019 [cited 2020 Dec 4 ];7:104-111
Available from: https://www.amhsjournal.org/article.asp?issn=2321-4848;year=2019;volume=7;issue=1;spage=104;epage=111;aulast=Mula;type=0