Year : 2020 | Volume
: 8 | Issue : 2 | Page : 221--224
Platelet count and indices in patients with psoriasis: Are they associated with disease severity?
Santosh Sharma1, Shakti Kumar Yadav1, Roshina Naeem1, Namrata Sarin1, VK Khurana2, Sompal Singh1
1 Department of Pathology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, Delhi, India
2 Department of Dermatology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, Delhi, India
Background and Aim: Psoriasis is an immunologically mediated chronic inflammatory skin disease. Altered platelets in psoriasis patients may have a role in predisposition to cardiovascular complications. The aim of this study is to study the platelet count (PLT) and indices in patients with psoriasis and to correlate platelet indices with Disease Area Severity Index score. Materials and Methods: The study was done in a tertiary care hospital. It was performed on 42 psoriasis patients (study group) and twenty healthy controls. Lifestyle factors, PLTs, and platelet indices were compared between psoriasis cases and controls. Correlation between these parameters and Psoriasis Area Severity Index (PASI) score was also studied in psoriasis patients. Chi-square test was applied to compare the categorical data from patients and controls. Spearman's rank correlation was used to correlate lifestyle factors with the severity of disease. Pearson's correlation coefficient was used to find the correlation between PASI and platelet parameters. Results: We found that PASI correlated with smoking (P = 0.042) and levels of psychological stress (P = 0.002). PLT (P = 0.043) and plateletcrit (P = 0.043) were significantly higher in the study group, whereas platelet distribution width (PDW) (P = 0.05) was lower in the study group. We found a significant correlation of PASI with PDW (P = 0.031), mean platelet volume (P = 0.050). and PLCR (0.028). Conclusion: Lifestyle factors such as smoking and levels of psychological stress play a significant role in psoriasis disease severity. There is a correlation of PLT and platelet indices with the pathogenesis and manifestation of disease.
Dr. Sompal Singh
Department of Pathology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, Delhi
|How to cite this article:|
Sharma S, Yadav SK, Naeem R, Sarin N, Khurana V K, Singh S. Platelet count and indices in patients with psoriasis: Are they associated with disease severity?.Arch Med Health Sci 2020;8:221-224
|How to cite this URL:|
Sharma S, Yadav SK, Naeem R, Sarin N, Khurana V K, Singh S. Platelet count and indices in patients with psoriasis: Are they associated with disease severity?. Arch Med Health Sci [serial online] 2020 [cited 2021 Jul 23 ];8:221-224
Available from: https://www.amhsjournal.org/article.asp?issn=2321-4848;year=2020;volume=8;issue=2;spage=221;epage=224;aulast=Sharma;type=0